Treatment with the whole tomato extracts affected key processes within the cells hindering their migration ability
Tomato extracts can inhibit the growth and malignant cloning of stomach cancer cells, according to a new study that paves the way for novel therapies to treat the deadly disease. Researchers analysed whole tomato extracts for their ability to tackle gastric cancer cell lines. “Their anti-tumoral effect seem not related to specific components, such as lycopene, but rather suggest that tomatoes should be considered in their entirety,” said Daniela Barone, researcher at the Oncology Research Centre of Mercogliano (CROM) in Italy.
Extracts of San Marzano and Corbarino tomato varieties were able to inhibit the growth and cloning behaviour of malignant cells.
Treatment with the whole tomato extracts affected key processes within the cells hindering their migration ability, arresting cell cycle through the modulation of retinoblastoma family proteins and specific cell cycle inhibitors, and ultimately inducing cancer cell death through apoptosis.
“Our results prompt further assessment of the potential use of specific nutrients not only in the cancer prevention setting but also as a supportive strategy along with conventional therapies,” said Antonio Giordano, professor at the University of Siena in Italy.
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